Einladung zur öffentlichen Disputation

von Herrn Nils Daniel Forkert

Dienstag, 16. April 2013, 14 Uhr c.t.

Universitätsklinikum Hamburg-Eppendorf
Martinistr. 52
Haus W36 (Institut für Computational Neuroscience)
EG, Raum 10a/b

"Model-Based Analysis of Cerebrovascular Diseases Combining 3D and 4D MRA Datasets"

Abstract:

Detailed knowledge about the vascular anatomy and blood flow at a macro- and microvascular level is of-ten required for diagnosis, therapy decision, and in-tervention in case of cerebrovascular diseases. This knowledge can, for example, be obtained from high resolution 3D and time-resolved three-dimensional magnetic resonance imaging datasets. However, advanced computer-assisted image analysis methods are required for an improved and faster rating of the massive amount of acquired data for diagnosis of patients with a cerebrovascular disease.

The first part of this dissertation describes the me-thodical contributions of this work including model-based approaches for the automatic segmentation of cerebrovascular structures, hemodynamic analysis, and combined visualization of vascular structures together with the corresponding hemodynamic situa-tion. Within this context, a multi-step segmentation framework for the automatic extraction of cerebro-vascular structures, including small and malformed vessels, from high-resolution 3D magnetic resonance angiographies is presented. Furthermore, the novel reference-based linear curve fitting approach for ana-lyzing the blood flow situation based on time-resolved 3D magnetic resonance imaging datasets, and a new 4D blood flow visualization technique, which enables a direct combined analysis and visualization of the cerebrovascular system and the corresponding blood flow situation at high spatial and temporal resolution, are presented.

The second part of this thesis highlights selected clinical studies with focus on cerebrovascular diseas-es, including arteriovenous malformations, aneu-rysms, and acute ischemic strokes, which were con-ducted using the developed methods described in the first part of this thesis.

Alle Mitglieder des Fachbereichs Informatik sind zu dieser öffentlichen Veranstaltung herzlich eingeladen.

Kontakt:

Prof. Dr. Matthias Rarey
Vorsitzender des Promotionsprüfungsausschusses